The Value of In Vitro Drug Activity and Pharmacokinetics in Predicting the Effectiveness of Anti mycobacterial Therapy: A Critical Review
WJ Burman - The American journal of the medical sciences, 1997 - Elsevier
Marked increases in case rates of drug-resistant tuberculosis and nontuberculous
mycobacterial infections have brought renewed urgency to the development of new
treatment regimens for mycobacterial infections. Preclinical data, such as in vitro measures
of drug activity and pharmacokinetics, are used in the design of new treatment regimens.
This review surveys the extensive published clinical experience concerning the treatment of
drug-susceptible tuberculosis to evaluate the use of these preclinical measures in predicting …
mycobacterial infections have brought renewed urgency to the development of new
treatment regimens for mycobacterial infections. Preclinical data, such as in vitro measures
of drug activity and pharmacokinetics, are used in the design of new treatment regimens.
This review surveys the extensive published clinical experience concerning the treatment of
drug-susceptible tuberculosis to evaluate the use of these preclinical measures in predicting …
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